Transmembrane emp24 domain-containing protein 9

Definition:

Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.

References:

[1]. G Emery, et al. Coupled transport of p24 family members. J Cell Sci. 2000 Jul;113 ( Pt 13):2507-16. [Content Brief]

[2]. Ruibai Luo, et al. Arf GAP2 is positively regulated by coatomer and cargo. Cell Signal. 2009 Jul;21(7):1169-79. [Content Brief]

[3]. Vijay Gupta, et al. Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER. J Cell Sci. 2006 May 1;119(Pt 9):1703-14. [Content Brief]

[4]. Gregory Emery, et al. The trans-membrane protein p25 forms highly specialized domains that regulate membrane composition and dynamics. J Cell Sci. 2003 Dec 1;116(Pt 23):4821-32. [Content Brief]

[5]. Sandra Mitrovic, et al. The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. Mol Biol Cell. 2008 May;19(5):1976-90. [Content Brief]

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