Transmembrane protein 147

Definition:

Component of a ribosome-associated endoplasmic reticulum (ER) translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Together with SEC61 and TMCO1, forms the lipid-filled cavity at the center of the translocon where TMEM147 may insert hydrophobic segments of mutli-pass membrane proteins from the lumen into de central membrane cavity in a process gated by SEC61, and TMCO1 may insert hydrophobic segments of nascent chains from the cytosol into the cavity. Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity.

References:

[1]. Philip T McGilvray, et al. An ER translocon for multi-pass membrane protein biogenesis. Elife. 2020 Aug 21;9:e56889. [Content Brief]

[2]. Erica Rosemond, et al. Regulation of M₃ muscarinic receptor expression and function by transmembrane protein 147. Mol Pharmacol. 2011 Feb;79(2):251-61. [Content Brief]

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