Transmembrane protein 170A

Definition:

Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins.

References:

[1]. Andri Christodoulou, et al. Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells. J Cell Sci. 2016 Apr 15;129(8):1552-65. [Content Brief]

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