Transmembrane protein 201

Definition:

Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery.; [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle. Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina.

References:

[1]. Balaje Vijayaraghavan, et al. Samp1, a RanGTP binding transmembrane protein in the inner nuclear membrane. Nucleus. 2016 Jul 3;7(4):415-23. [Content Brief]

[2]. Santhosh Gudise, et al. Samp1 is functionally associated with the LINC complex and A-type lamina networks. J Cell Sci. 2011 Jun 15;124(Pt 12):2077-85. [Content Brief]

[3]. Charlotta Buch, et al. An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells. J Cell Sci. 2009 Jun 15;122(Pt 12):2100-7. [Content Brief]

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