Transmembrane protein 59-like

Definition:

Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.

References:

[1]. Sylvia Ullrich, et al. The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. J Biol Chem. 2010 Jul 2;285(27):20664-74. [Content Brief]

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