Transmembrane protein 88

Definition:

Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.

References:

[1]. Nathan J Palpant, et al. Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development. Development. 2013 Sep;140(18):3799-808. [Content Brief]

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