Trem-like transcript 2 protein

Definition:

Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.

References:

[1]. Richard J N Allcock, et al. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur J Immunol. 2003 Feb;33(2):567-77. [Content Brief]

[2]. Masaaki Hashiguchi, et al. Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10495-500. [Content Brief]

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