Triggering receptor expressed on myeloid cells 1

Definition:

[Isoform 1]: Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis.; [Isoform 2]: Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its lignad.

References:

[1]. Rob J W Arts, et al. TREM-1 interaction with the LPS/TLR4 receptor complex. Eur Cytokine Netw. 2011 Mar;22(1):11-4. [Content Brief]

[2]. Tereza Ormsby, et al. Btk is a positive regulator in the TREM-1/DAP12 signaling pathway. Blood. 2011 Jul 28;118(4):936-45. [Content Brief]

[3]. A Bouchon, et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature. 2001 Apr 26;410(6832):1103-7. [Content Brief]

[4]. Sergei Radaev, et al. Crystal structure of the human myeloid cell activating receptor TREM-1. Structure. 2003 Dec;11(12):1527-35. [Content Brief]

[5]. Christine B Read, et al. Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1. J Immunol. 2015 Feb 15;194(4):1417-21. [Content Brief]

[6]. Kevin Carrasco, et al. TREM-1 multimerization is essential for its activation on monocytes and neutrophils. Cell Mol Immunol. 2019 May;16(5):460-472. [Content Brief]

[7]. Sankar Baruah, et al. Identification of a Novel Splice Variant Isoform of TREM-1 in Human Neutrophil Granules. J Immunol. 2015 Dec 15;195(12):5725-31. [Content Brief]

[8]. Rabab El Mezayen, et al. Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol Lett. 2007 Jul 31;111(1):36-44. [Content Brief]

[9]. A Bouchon, et al. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000 May 15;164(10):4991-5. [Content Brief]

[10]. Carl F Fortin, et al. Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4. Int Immunol. 2007 Jan;19(1):41-50. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.