Trinucleotide repeat-containing gene 6C protein

Definition:

Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.

References:

[1]. Joerg E Braun, et al. GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. Mol Cell. 2011 Oct 7;44(1):120-33. [Content Brief]

[2]. Jakob T Zipprich, et al. Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. RNA. 2009 May;15(5):781-93. [Content Brief]

[3]. Marina Chekulaeva, et al. miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs. Nat Struct Mol Biol. 2011 Oct 7;18(11):1218-26. [Content Brief]

[4]. Marc R Fabian, et al. miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. Nat Struct Mol Biol. 2011 Oct 7;18(11):1211-7. [Content Brief]

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