Tripeptidyl-peptidase 2

Definition:

Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It plays an important role in intracellular amino acid homeostasis. Stimulates adipogenesis (By similarity).

References:

[1]. Wei Lu, et al. Dual proteolytic pathways govern glycolysis and immune competence. Cell. 2014 Dec 18;159(7):1578-90. [Content Brief]

[2]. Eva M Reinthaler, et al. TPP2 mutation associated with sterile brain inflammation mimicking MS. Neurol Genet. 2018 Nov 13;4(6):e285. [Content Brief]

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