Tryptophan 2,3-dioxygenase

Definition:

Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.

References:

[1]. Bing Meng, et al. Structural and functional analyses of human tryptophan 2,3-dioxygenase. Proteins. 2014 Nov;82(11):3210-6. [Content Brief]

[2]. Patrick Ferreira, et al. Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency. Mol Genet Metab. 2017 Apr;120(4):317-324. [Content Brief]

[3]. Ariel Lewis-Ballester, et al. Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase. Sci Rep. 2016 Oct 20;6:35169. [Content Brief]

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