Tubby protein homolog

Definition:

Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.

References:

[1]. Nora B Caberoy, et al. Identification of tubby and tubby-like protein 1 as eat-me signals by phage display. Exp Cell Res. 2010 Jan 15;316(2):245-57. [Content Brief]

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