Tumor necrosis factor receptor superfamily member 11B

Definition:

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

References:

[1]. Xudong Luan, et al. Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin. J Immunol. 2012 Jul 1;189(1):245-52. [Content Brief]

[2]. E Tsuda, et al. Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun. 1997 May 8;234(1):137-42. [Content Brief]

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