Type-1 angiotensin II receptor-associated protein

Definition:

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

References:

[1]. Marco Lopez-Ilasaca, et al. The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling. Mol Biol Cell. 2003 Dec;14(12):5038-50. [Content Brief]

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