Tyrosine-protein phosphatase non-receptor type 14

Definition:

Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.

References:

[1]. Wenqi Wang, et al. PTPN14 is required for the density-dependent control of YAP1. Genes Dev. 2012 Sep 1;26(17):1959-71. [Content Brief]

[2]. X Liu, et al. PTPN14 interacts with and negatively regulates the oncogenic function of YAP. Oncogene. 2013 Mar 7;32(10):1266-73. [Content Brief]

[3]. Audrey C Au, et al. Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans. Am J Hum Genet. 2010 Sep 10;87(3):436-44. [Content Brief]

[4]. Michael Benzinou, et al. Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia. Nat Commun. 2012 Jan 10;3:616. [Content Brief]

[5]. Leila Wyatt, et al. The protein tyrosine phosphatase Pez regulates TGFbeta, epithelial-mesenchymal transition, and organ development. J Cell Biol. 2007 Sep 24;178(7):1223-35. [Content Brief]

[6]. Carol Wadham, et al. The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin. Mol Biol Cell. 2003 Jun;14(6):2520-9. [Content Brief]

[7]. C Wadham, et al. Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation. J Cell Sci. 2000 Sep;113 ( Pt 17):3117-23. [Content Brief]

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