Ubiquitin carboxyl-terminal hydrolase 3

Definition:

Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.

References:

[1]. Francesco Nicassio, et al. Human USP3 is a chromatin modifier required for S phase progression and genome stability. Curr Biol. 2007 Nov 20;17(22):1972-7. [Content Brief]

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