Unconventional myosin-VIIb

Definition:

Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli (Probable).

References:

[1]. Scott W Crawley, et al. ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation. Dev Cell. 2016 Jan 25;36(2):190-200. [Content Brief]

[2]. Scott W Crawley, et al. Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion. Cell. 2014 Apr 10;157(2):433-446. [Content Brief]

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