USP6 N-terminal-like protein

Definition:

Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.

References:

[1]. L Lanzetti, et al. The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. Nature. 2000 Nov 16;408(6810):374-7. [Content Brief]

[2]. Evelyn Fuchs, et al. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. J Cell Biol. 2007 Jun 18;177(6):1133-43. [Content Brief]

[3]. Alexander K Haas, et al. Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells. J Cell Sci. 2007 Sep 1;120(Pt 17):2997-3010. [Content Brief]

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