Viridans group streptococcal infection

Definition:

The viridans group streptococci (VGS), a heterogenous group of streptococcal species, are the predominant species of the human oral flora and commonly inhabit other areas of the upper respiratory, gastrointestinal, and female genital tracts. VGS are usually organisms of low virulence. However, VGS are a major cause of sepsis and pneumonia in neutropenic individuals, and an important cause of sepsis and meningitis in neonates. These organisms are also occasional pathogens in healthy children and adults, causing infections such as subacute endocarditis. Although VGS resistance to penicillin and the macrolide-lincosamide-streptogramin B (MLS) drugs is an evolving problem, several drugs remain uniformly active against the VGS. Thus far, VGS resistance to vancomycin, linezolid, and daptomycin remains extremely rare.

References:

[1]. Anne F Reilly, et al. Infections with viridans group streptococci in children with cancer. Pediatr Blood Cancer. 2007 Nov;49(6):774-80. [Content Brief]

[2]. Christopher D Doern, et al. It's not easy being green: the viridans group streptococci, with a focus on pediatric clinical manifestations. J Clin Microbiol. 2010 Nov;48(11):3829-35. [Content Brief]

[3]. J L Shenep, et al. Viridans-group streptococcal infections in immunocompromised hosts. Int J Antimicrob Agents. 2000 Mar;14(2):129-35. [Content Brief]

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