Vitiligo

Definition:

Vitiligo is a common, multifactorial, polygenic disease in which autoimmune loss of melanocytes results in depigmented spots of skin, overlying hair, and mucous membranes. Some familial forms of vitiligo have recently been linked to polymorphisms in the innate immunity gene, NLRP1.

References:

[1]. Andrea D'Osualdo, et al. NLRP1, a regulator of innate immunity associated with vitiligo. Pigment Cell Melanoma Res. 2012 Jan;25(1):5-8. [Content Brief]

[2]. Jo Ana Schunter, et al. A novel FoxD3 Variant Is Associated With Vitiligo and Elevated Thyroid Auto-Antibodies. J Clin Endocrinol Metab. 2015 Oct;100(10):E1335-42. [Content Brief]

[3]. Roberta Colucci, et al. Vitiligo: an update on current pharmacotherapy and future directions. Expert Opin Pharmacother. 2012 Sep;13(13):1885-99. [Content Brief]

[4]. Ying Jin, et al. Genetic variations in NALP1 are associated with generalized vitiligo in a Romanian population. J Invest Dermatol. 2007 Nov;127(11):2558-62. [Content Brief]

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