White sponge nevus

Definition:

White sponge nevus is a benign autosomal dominant disorder affecting non-cornifying stratified squamous epithelia with white spongy plaques in the mouth. Mutations in KRT4 and KRT13, which are expressed in the mucosal non-cornifying stratified epithelia, are associated with the disease.

References:

[1]. E L Rugg, et al. A mutation in the mucosal keratin K4 is associated with oral white sponge nevus. Nat Genet. 1995 Dec;11(4):450-2. [Content Brief]

[2]. Frances Smith, et al. The molecular genetics of keratin disorders. Am J Clin Dermatol. 2003;4(5):347-64. [Content Brief]

[3]. G Richard, et al. Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus. Nat Genet. 1995 Dec;11(4):453-5. [Content Brief]

[4]. L D Corden, et al. Human keratin diseases: hereditary fragility of specific epithelial tissues. Exp Dermatol. 1996 Dec;5(6):297-307. [Content Brief]

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