X-linked retinitis pigmentosa GTPase regulator

Definition:

Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity). May be involved in microtubule organization and regulation of transport in primary cilia.

References:

[1]. Milica Gakovic, et al. The role of RPGR in cilia formation and actin stability. Hum Mol Genet. 2011 Dec 15;20(24):4840-50. [Content Brief]

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