2. PROTAC
  3. PROTAC Linkers
  4. Bis-aminooxy-PEG1

Bis-aminooxy-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Bis-aminooxy-PEG1 Chemical Structure

Bis-aminooxy-PEG1 Chemical Structure

CAS No. : 93460-33-4

Size Price Stock Quantity
100 mg USD 230 In-stock
250 mg USD 420 In-stock
500 mg USD 630 In-stock
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5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

Bis-aminooxy-PEG1 Related Antibodies

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Description

Bis-aminooxy-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bis-aminooxy-PEG1 Related Antibodies
Molecular Weight

136.15

Formula

C4H12N2O3
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

NOCCOCCON
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (734.48 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.3448 mL 36.7242 mL 73.4484 mL
5 mM 1.4690 mL 7.3448 mL 14.6897 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.3448 mL 36.7242 mL 73.4484 mL 183.6210 mL
5 mM 1.4690 mL 7.3448 mL 14.6897 mL 36.7242 mL
10 mM 0.7345 mL 3.6724 mL 7.3448 mL 18.3621 mL
15 mM 0.4897 mL 2.4483 mL 4.8966 mL 12.2414 mL
20 mM 0.3672 mL 1.8362 mL 3.6724 mL 9.1811 mL
25 mM 0.2938 mL 1.4690 mL 2.9379 mL 7.3448 mL
30 mM 0.2448 mL 1.2241 mL 2.4483 mL 6.1207 mL
40 mM 0.1836 mL 0.9181 mL 1.8362 mL 4.5905 mL
50 mM 0.1469 mL 0.7345 mL 1.4690 mL 3.6724 mL
60 mM 0.1224 mL 0.6121 mL 1.2241 mL 3.0604 mL
80 mM 0.0918 mL 0.4591 mL 0.9181 mL 2.2953 mL
100 mM 0.0734 mL 0.3672 mL 0.7345 mL 1.8362 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Bis-aminooxy-PEG1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis-aminooxy-PEG193460-33-4PROTAC LinkersInhibitorinhibitorinhibit

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