BKM-570

Cat. No.: HY-123560: FAQs
Data Sheet Handling Instructions Technical Support

BKM-570 is a nonpeptide bradykinin antagonist with anticancer effects. BKM-570 can be used in the study of lung cancer, prostate cancer and ovarian cancer.

For research use only. We do not sell to patients.

BKM-570 Chemical Structure

CAS No. : 259885-54-6

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Biological Activity
Purity & Documentation
References
Customer Review

Description

BKM-570 is a nonpeptide bradykinin antagonist with anticancer effects. BKM-570 can be used in the study of lung cancer, prostate cancer and ovarian cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
C6	IC₅₀	4 μM Compound: BKM-570	Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
Cancer cell lines	IC₅₀	1.8 μM Compound: BKM-570	Cytotoxicity against human Small cell lung cancer cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human Small cell lung cancer cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
Granta	IC₅₀	63.3 μM Compound: BKM-570	Cytotoxicity against human Granta cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human Granta cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
HEK293	IC₅₀	3.8 μM Compound: BKM-570	Cytotoxicity against HEK293 cells overexpressing CHI3L1 gene assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against HEK293 cells overexpressing CHI3L1 gene assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
JeKo-1	IC₅₀	49.3 μM Compound: BKM-570	Cytotoxicity against human Jeko cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human Jeko cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
U-373MG ATCC	IC₅₀	3.3 μM Compound: BKM-570	Cytotoxicity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]

Molecular Weight

698.55

Formula

C₃₄H₃₄Cl₂F₅N₃O₃

CAS No.

259885-54-6

SMILES

O=C([C@@H](NC(/C=C/C1=C(C(F)=C(C(F)=C1F)F)F)=O)CC2=CC=C(C=C2)OCC3=C(C=CC=C3Cl)Cl)NC4CC(C)(C)NC(C)(C)C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Stephanie Jutras, et al. Strong cytotoxic effect of the bradykinin antagonist BKM-570 in ovarian cancer cells--analysis of the molecular mechanisms of its antiproliferative action. FEBS J. 2010 Dec;277(24):5146-60. [Content Brief]

BKM-570 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BKM-570259885-54-6BKM570BKM 570Bradykinin Receptorbradykinin antagonistlung cancerprostate cancer and ovarian cancerInhibitorinhibitorinhibit

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