2. Immunology/Inflammation Apoptosis
  3. PD-1/PD-L1 Apoptosis
  4. BMS-202 hydrochloride

BMS-202 hydrochloride is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC50 of 18 nM and a KD of 8 μM. BMS-202 hydrochloride binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 hydrochloride has antitumor activity.

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BMS-202 hydrochloride Chemical Structure

BMS-202 hydrochloride Chemical Structure

CAS No. : 2089334-95-0

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BMS-202 hydrochloride Related Antibodies

Top Publications Citing Use of Products

    BMS-202 hydrochloride purchased from MedChemExpress. Usage Cited in: Drug Dev Res. 2021 Jul 26.  [Abstract]

    Cultured Lβt2 cells are treated with 25 μM BMS-202 and collected at 24 h. the p-p38 MAPK, p38 MAPK, p-JNK, JNK, p-ERK, ERK, and α-tubulin protein levels are detected by Western Blotting.

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    Description

    BMS-202 hydrochloride is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC50 of 18 nM and a KD of 8 μM. BMS-202 hydrochloride binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 hydrochloride has antitumor activity[1][2].

    Molecular Weight

    455.98

    Formula

    C25H30ClN3O3
    CAS No.
    SMILES

    CC(NCCNCC1=CC=C(OCC2=C(C)C(C3=CC=CC=C3)=CC=C2)N=C1OC)=O.[H]Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    BMS-202 hydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    BMS-2022089334-95-0BMS202BMS 202PD-1/PD-L1ApoptosisPD-1/Programmed death-ligand 1Thermal stabilizationnonpeptidicdimerichydrophobicantitumoranti-proliferationimmune-responseInhibitorinhibitorinhibit

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