2. PROTAC
  3. Molecular Glues
  4. BMS-986449

BMS-986449 is a CELMoD molecular glue targeting the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors.

For research use only. We do not sell to patients.

BMS-986449 Chemical Structure

BMS-986449 Chemical Structure

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BMS-986449 Related Antibodies

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Description

BMS-986449 is a CELMoD molecular glue targeting the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors[1].

Molecular Weight

396.41

Formula

C21H21FN4O3
SMILES

NC1=NC(C2=C(F)C([C@@H](C)N([C@H]3CCC(NC3=O)=O)C4=O)=C4C=C2)=CC(C)=C1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BMS-986449 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-986449BMS986449BMS 986449Molecular Gluesmolecular glueHeliosEosregulatory T (Treg) cellsadvanced solid tumorsInhibitorinhibitorinhibit

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