BN201 

BN201 promotes neuronal differentiation, the differentiation of precursor cells to mature oligodendrocytes (EC₅₀ of 6.3 μM) in vitro, and the myelination of new axons (EC₅₀ of 16.6 μM). BN201 is able to cross the blood-brain barrier by active transport and activate pathways (IGF-1 pathway) associated with the response to stress and neuron survival. BN201 has potently neuroprotective effects^[1].

BN201 (10 μM; 0.5-4 hours; Hela cells) treatment induces the phosphorylation of NDGR1 in Hela cells in a time-dependent manner^[1].
BN201 promotes the survival of cultured neural cells when subjected to oxidative stress or when deprived of trophic factors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BN201 (12.5-150 mg/kg; intraperitoneal injection; daily; for 30 days; female C57BL/6 mice) treatment displays less axonal loss and neuron loss in both the spinal cord and in the optic nerve than the animals that received placebo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

491.60

C₂₅H₃₈FN₅O₄

1361200-34-1

O=C(N)CN(C(CN(C(CNCCC1=CC=CC=C1F)=O)CC(C)C)=O)CCCN2C(CCC2)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Villoslada P, et al. Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation. Neurotherapeutics. 2019 Jul;16(3):808-827.  [Content Brief]