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BN201 promotes neuronal differentiation, the differentiation of precursor cells to mature oligodendrocytes (EC50 of 6.3 μM) in vitro, and the myelination of new axons (EC50 of 16.6 μM). BN201 is able to cross the blood-brain barrier by active transport and activate pathways (IGF-1 pathway) associated with the response to stress and neuron survival. BN201 has potently neuroprotective effects.

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BN201 Chemical Structure

BN201 Chemical Structure

CAS No. : 1361200-34-1

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BN201 Related Antibodies

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Description

BN201 promotes neuronal differentiation, the differentiation of precursor cells to mature oligodendrocytes (EC50 of 6.3 μM) in vitro, and the myelination of new axons (EC50 of 16.6 μM). BN201 is able to cross the blood-brain barrier by active transport and activate pathways (IGF-1 pathway) associated with the response to stress and neuron survival. BN201 has potently neuroprotective effects[1].

In Vitro

BN201 (10 μM; 0.5-4 hours; Hela cells) treatment induces the phosphorylation of NDGR1 in Hela cells in a time-dependent manner[1].
BN201 promotes the survival of cultured neural cells when subjected to oxidative stress or when deprived of trophic factors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BN201 Related Antibodies

Western Blot Analysis[1]

Cell Line: Hela cells
Concentration: 10 μM
Incubation Time: 0.5 hour, 1 hour, 4 hours
Result: Induced the phosphorylation of NDGR1 in Hela cells in a dose- and time-dependent manner.
In Vivo

BN201 (12.5-150 mg/kg; intraperitoneal injection; daily; for 30 days; female C57BL/6 mice) treatment displays less axonal loss and neuron loss in both the spinal cord and in the optic nerve than the animals that received placebo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 mice (8-12 weeks old) by immunization with MOG35-55 (experimental autoimmune encephalitis , EAE)[1]
Dosage: 12.5 mg/kg, 25 mg/kg, 50 mg/kg, 100 mg/kg, 150 mg/kg
Administration: Intraperitoneal injection; daily; for 30 days
Result: Displayed less axonal loss and neuron loss in both the spinal cord and in the optic nerve than the animals that received placebo.
Clinical Trial
Molecular Weight

491.60

Formula

C25H38FN5O4
CAS No.
SMILES

O=C(N)CN(C(CN(C(CNCCC1=CC=CC=C1F)=O)CC(C)C)=O)CCCN2C(CCC2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BN201 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BN2011361200-34-1BN 201BN-201OthersNeuroprotectiveneuronsmyelin-formingdifferentiationNDGR1multiplesclerosisBBBopticneuritisIGF-1Inhibitorinhibitorinhibit

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