Boc-bipiperidine-ethynylbenzoic acid

Name: Boc-bipiperidine-ethynylbenzoic acid
Brand: MedChemExpress
SKU: HY-139661
Rating: 4.5 (1 reviews)

Cat. No.: HY-139661 Purity: 99.19%: FAQs
Data Sheet SDS COA Handling Instructions

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Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61. Boc-bipiperidine-ethynylbenzoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Boc-bipiperidine-ethynylbenzoic acid Chemical Structure

CAS No. : 2308497-81-4

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5 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 560	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 860	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61^[1]. Boc-bipiperidine-ethynylbenzoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target^[1]

Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

412.52

Formula

C₂₄H₃₂N₂O₄

CAS No.

2308497-81-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C=C1)C#CC2CCN(C3CCN(CC3)C(OC(C)(C)C)=O)CC2)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: 99.19%

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Data Sheet (265 KB) SDS (252 KB)

COA (245 KB) HNMR (266 KB) LCMS (106 KB)

Handling Instructions (2659 KB)

References

[1]. Lijie Zhao, et al. A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo. Neoplasia. 2020 Oct;22(10):522-532. [Content Brief]