2. Apoptosis Epigenetics
  3. c-Myc Epigenetic Reader Domain Apoptosis
  4. BRD4 Inhibitor-18

BRD4 Inhibitor-18 is a highly potent BRD4 inhibitor with an IC50 value of 110 nM. BRD4 Inhibitor-18 has a hydrophobic acetylcyclopentanyl side chain. BRD4 Inhibitor-18 can significantly suppress the proliferation of MV-4-11 cells with high BRD4 level. BRD4 Inhibitor-18 has apoptosis-promoting and G0/G1 cycle-arresting activity.

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BRD4 Inhibitor-18 Chemical Structure

BRD4 Inhibitor-18 Chemical Structure

CAS No. : 2451219-73-9

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BRD4 Inhibitor-18 Related Antibodies

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Description

BRD4 Inhibitor-18 is a highly potent BRD4 inhibitor with an IC50 value of 110 nM. BRD4 Inhibitor-18 has a hydrophobic acetylcyclopentanyl side chain. BRD4 Inhibitor-18 can significantly suppress the proliferation of MV-4-11 cells with high BRD4 level. BRD4 Inhibitor-18 has apoptosis-promoting and G0/G1 cycle-arresting activity[1].

IC50 & Target

BRD4

110 nM (IC50)

In Vitro

BRD4 Inhibitor-18 (compound 13f) (0-10 μM; 72 hours) can suppress the proliferation of HL-60 and MV-41 cells[1].
BRD4 Inhibitor-18 (0.5 and 5 μM; 12 hours) significantly arrests MV-4-11 cells in G1 phase in a dose-dependent manner[1].
BRD4 Inhibitor-18 (0.5 and 5 μM; 12 hours) effectively induces apoptosis of MV-4-11 cells in a dose-dependent manner[1].
BRD4 Inhibitor-18 (0.5 and 5 μM; 4 hours) inhibits the expression of c-Myc protein in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BRD4 Inhibitor-18 Related Antibodies

Cell Proliferation Assay

Cell Line: HL-60 and MV-4-11[1]
Concentration: 0-10 μM
Incubation Time: 72 hours
Result: Suppressed the proliferation of HL-60 and MV-41 cells with IC50s of 5.52 μM and 0.42 μM.

Cell Cycle Analysis

Cell Line: MV-4-11 cells[1]
Concentration: 0.5 and 5 μM
Incubation Time: 12 hours
Result: Significantly arrested MV-4-11 cells in G1 phase, with the G0/G1 cell proportions of 50.87% and 70.66% at 0.5 and 5 μM.

Apoptosis Analysis

Cell Line: MV-4-11 cells[1]
Concentration: 0.5 and 5 μM
Incubation Time: 12 hours
Result: Effectively induced apoptosis of MV-4-11 cells, with apoptosis rates of 12.39% and 73.24% at at 0.5 and 5 μM.

Western Blot Analysis

Cell Line: MV-4-11 cells[1]
Concentration: 0.5 and 5 μM
Incubation Time: 4 hours
Result: Inhibited the expression of c-Myc protein in a dose-dependent manner.
Molecular Weight

496.02

Formula

C26H26ClN3O3S
CAS No.
SMILES

COC1=CC2=C(C=C1)C3=C(SC(N3C)=O)C(CC(NC4CCCC4)=O)N=C2C5=CC=C(Cl)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BRD4 Inhibitor-18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD4 Inhibitor-182451219-73-9c-MycEpigenetic Reader DomainApoptosisMycAnticancerMV-4-11 cellsCell cycleAnti-proliferationInhibitorinhibitorinhibit

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