2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. Brinzolamide hydrochloride

Brinzolamide hydrochloride  (Synonyms: AL-4862 hydrochloride)

Cat. No.: HY-B0588A
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Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC50 value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research.

For research use only. We do not sell to patients.

Brinzolamide hydrochloride Chemical Structure

Brinzolamide hydrochloride Chemical Structure

CAS No. : 150937-43-2

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Brinzolamide hydrochloride Related Antibodies

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Description

Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC50 value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research[1][2].

IC50 & Target[1]

hCA II

3.2 nM (IC50)

In Vivo

Brinzolamide (7.5 mg or 12 mg) hydrochloride implanted in a silicone matrix is extremely well tolerated and provides sustained release of brinzolamide and significant reduction in intraocular pressure (IOP) for up to 28 days with no adverse effects or signs of toxicity in normotensive NZW rabbits[2].
The pharmacokinetic parameters of Brinzolamide hydrochloride in rabbits[1].

Intracameral Administration (4.5 mg) Intracameral Administration (4.5 mg) Topical Administration (500 mg) Topical Administration (500 mg)
PK Parameters Aqueous Humor Iris-Ciliary Body Aqueous Humor Iris-Ciliary Body
Tmax (h) 0.08 0.5 1 0.25
Cmax (ng/mL, ng/g) 11,050 1964 408 1245
Terminal t1/2 (h) 3.4 13 2 13.6
AUC0-24h (h*ng/mL, h*ng/g) 17,780 7725 1896 11414
AUC0-∞ (h*ng/mL, h*ng/g) 17,836 8839 1955 16628
Dose-normalized AUC0-∞ (h*/mL, h*/g) 4 2 0.004 0.03

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rabbits[2]
Dosage: 7.5 mg, 12 mg
Administration: Implant placed in the episcleral space
Result: Resulted in a significant IOP reduction of 4.6 mmHg on days 10-28, with concentrations of 12 mg.
Clinical Trial
Molecular Weight

419.97

Formula

C12H22ClN3O5S3
CAS No.
SMILES

O=S(C(S1)=CC2=C1S(N(CCCOC)C[C@@H]2NCC)(=O)=O)(N)=O.Cl[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Brinzolamide hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Brinzolamide150937-43-2AL-4862AL4862AL 4862Carbonic AnhydraseCarbonate dehydratasecarbonic anhydrase IIintraocular pressureIOPatrial fluidglaucomaInhibitorinhibitorinhibit

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