Britannilactone diacetate (Synonyms: 1,6-O,O-Diacetylbritannilactone; Di-O-acetylbritannilactone)

Cat. No.: HY-N4190: FAQs
Data Sheet Handling Instructions Technical Support

Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by LPS in BV-2 microglial cells with the EC₅₀ value of 6.3 μM. Britannilactone diacetate exhibits a favorable blood-brain barriers (BBB) penetration and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property.

For research use only. We do not sell to patients.

Britannilactone diacetate Chemical Structure

CAS No. : 1286694-67-4

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	EC₅₀	6.3 μM Compound: 2; OABL	Inhibition of LPS-induced NO production in mouse BV-2 cells incubated for 24 hrs by Griess reagent based assay Inhibition of LPS-induced NO production in mouse BV-2 cells incubated for 24 hrs by Griess reagent based assay	[PMID: 34315042]
HCT-116	IC₅₀	10.1 μM Compound: OABL	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	10.1039/C4MD00209A
HeLa	IC₅₀	11.2 μM Compound: OABL	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	10.1039/C4MD00209A
SGC-7901	IC₅₀	15.9 μM Compound: OABL	Cytotoxicity against human SGC7901 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Cytotoxicity against human SGC7901 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	10.1039/C4MD00209A

Molecular Weight

350.41

Formula

C₁₉H₂₆O₆

CAS No.

1286694-67-4

SMILES

O=C1O[C@@]2([H])[C@@]([C@H](OC(C)=O)C([C@@H](C)CCCOC(C)=O)=C(C)C2)([H])C1=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tang JJ, et al. 1,10-Seco-Eudesmane sesquiterpenoids as a new type of anti-neuroinflammatory agents by suppressing TLR4/NF-κB/MAPK pathways. Eur J Med Chem. 2021 Nov 15;224:113713. [Content Brief]

Britannilactone diacetate Related Classifications

Neurological Disease Inflammation/Immunology

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Britannilactone diacetate1286694-67-41,6-O,O-Diacetylbritannilactone Di-O-acetylbritannilactoneNO SynthaseNitric oxide synthasesNOSMacrophageRAW264.7 cellsNitric oxideNOInhibitorinhibitorinhibit

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