2. PROTAC Antibody-drug Conjugate/ADC Related
  3. PROTAC Linkers ADC Linker
  4. Bromoacetamido-PEG4-acid

Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Bromoacetamido-PEG4-acid Chemical Structure

Bromoacetamido-PEG4-acid Chemical Structure

CAS No. : 1807518-67-7

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Based on 1 publication(s) in Google Scholar

Bromoacetamido-PEG4-acid Related Antibodies

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Description

Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC50 & Target

PEGs

 

Cleavable Linker

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bromoacetamido-PEG4-acid Related Antibodies
Molecular Weight

386.24

Formula

C13H24BrNO7
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(O)CCOCCOCCOCCOCCNC(CBr)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 96.82%

COA (240 KB) LCMS (90 KB)

Handling Instructions (2659 KB)
References
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Bromoacetamido-PEG4-acid Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bromoacetamido-PEG4-acid1807518-67-7PROTAC LinkersADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Product Name:
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Cat. No.:
HY-141382
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