Brostallicin (Synonyms: PNU-166196)

Cat. No.: HY-16117A: FAQs
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Brostallicin (PNU-166196) is a DNA alkylating agent with potent cytotoxicity and low myelotoxicity.

For research use only. We do not sell to patients.

Brostallicin Chemical Structure

CAS No. : 203258-38-2

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Description

Brostallicin (PNU-166196) is a DNA alkylating agent with potent cytotoxicity and low myelotoxicity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC₅₀	0.64 nM Compound: 17 (brostallicin)	Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells,(cells resistant to melphalan (L-PAM) Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells,(cells resistant to melphalan (L-PAM)	[PMID: 15115402]
L1210	IC₅₀	1.8 nM Compound: 9	In vitro cytotoxicity against L1210 murine leukemia cells after 48 hr of continuous exposure In vitro cytotoxicity against L1210 murine leukemia cells after 48 hr of continuous exposure	[PMID: 12031321]
L1210	IC₅₀	2.13 nM Compound: 17 (brostallicin)	Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells	[PMID: 15115402]

Molecular Weight

760.04

Formula

C₃₀H₃₆BrClN₁₂O₅

CAS No.

203258-38-2

SMILES

O=C(C(Br)=C)NC1=CN(C)C(C(NC2=CN(C)C(C(NC3=CN(C)C(C(NC4=CN(C)C(C(NCCNC(N)=N)=O)=C4)=O)=C3)=O)=C2)=O)=C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Brostallicin (PNU-166196), a new minor groove DNA binder: preclinical and clinical activity

Brostallicin Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Brostallicin203258-38-2PNU-166196PNU166196PNU 166196OthersInhibitorinhibitorinhibit

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