BTK inhibitor 19

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BTK inhibitor 19 is a highly selective, covalent BTK inhibitor (IC₅₀ = 2.7 nM).

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BTK inhibitor 19 Chemical Structure

CAS No. : 2557174-19-1

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Description

BTK inhibitor 19 is a highly selective, covalent BTK inhibitor (IC₅₀ = 2.7 nM).

Cellular Effect

Cell Line	Type	Value	Description	References
MOLM-13	IC₅₀	3.7 μM Compound: 26	Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay	[PMID: 34672559]
NAMALVA	IC₅₀	4.1 μM Compound: 26	Antiproliferative activity against human NAMALWA cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay Antiproliferative activity against human NAMALWA cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay	[PMID: 34672559]
Pfeiffer	IC₅₀	2.5 μM Compound: 26	Antiproliferative activity against human Pfeiffer cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay Antiproliferative activity against human Pfeiffer cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay	[PMID: 34672559]
Raji	IC₅₀	4.3 μM Compound: 26	Antiproliferative activity against human Raji cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay Antiproliferative activity against human Raji cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay	[PMID: 34672559]
Ramos	IC₅₀	2.5 μM Compound: 26	Antiproliferative activity against human Ramos cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay Antiproliferative activity against human Ramos cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay	[PMID: 34672559]
Rec1	IC₅₀	0.035 μM Compound: 26	Antiproliferative activity against human REC-1 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay Antiproliferative activity against human REC-1 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay	[PMID: 34672559]
SU-DHL-2	IC₅₀	5.5 μM Compound: 26	Antiproliferative activity against human SUDHL2 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay Antiproliferative activity against human SUDHL2 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay	[PMID: 34672559]
TMD8	IC₅₀	0.025 μM Compound: 26	Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay	[PMID: 34672559]

Molecular Weight

527.50

Formula

C₂₅H₂₄F₃N₇O₃

CAS No.

2557174-19-1

SMILES

NC(C1=C(C2=CC=C(C(NC3=NC=CC(C(F)(F)F)=C3)=O)C=C2)N=C([C@@H]4CCCCN4C(C=C)=O)N1N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ma C, et al. Discovery of 1-Amino-1H-imidazole-5-carboxamide Derivatives as Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitors. J Med Chem. 2021 Nov 11;64(21):16242-16270. [Content Brief]

BTK inhibitor 19 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTK inhibitor 192557174-19-1BTK inhibitor19BTK inhibitor-19BtkBruton tyrosine kinaseInhibitorinhibitorinhibit

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