Butibufen

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Butibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation.

For research use only. We do not sell to patients.

Butibufen Chemical Structure

CAS No. : 55837-18-8

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Description

Butibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation^[1]^[2].

In Vitro

Butibufen (0.1 μM-0.1 M; 60 min) affects cell viability and cell attachment with a high dose^[2].
Butibufen (1 μM; 48 h) causes a 100% cell death after 48 h exposure^[2].
Butibufen (2 μM-1 mM; 6 h) affects synthesis of albumin in hepatocytes^[2].
Butibufen (0.2-0.4 mM; 6 h) impaires gluconeogenesis from lactate and significantly inhibited ureogenesis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	Hepatocytes from Sprague-Dawley male rats
Concentration:	0.1 μM-0.1 M
Incubation Time:	60 min
Result:	Showed no cell viability effects under the dose of 200 μM, but dose- and time-dependently affected cell viability with higher concentrations.

In Vivo

Butibufen (50 and 250 mg/kg; p.o. 8 and 3 h before sacrifice) affects acid phosphatase activity^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley rats^[3]
Dosage:	50 and 250 mg/kg
Administration:	Oral gavage; 50 and 250 mg/kg; 8 and 3 h before sacrifice
Result:	Reduced acid phosphatase activity but showed no effect on the stabilization of lysosomal membrane.

Molecular Weight

220.31

Formula

C₁₄H₂₀O₂

CAS No.

55837-18-8

SMILES

CCC(C(O)=O)C1=CC=C(C=C1)CC(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Aparicio L. Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent. Arch Int Pharmacodyn Ther. 1977 May;227(1):130-41. [Content Brief]

[2]. Castell JV, et al. A study of the relative hepatotoxicity in vitro of the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen and butibufen. Xenobiotica. 1988 Jun;18(6):737-45. [Content Brief]

[3]. Alamo C, et al. Influence of butibufen on enzyme activity and lysosomal stabilization ex vivo: a comparative study with hydrocortisone and acetylsalicylic acid. Methods Find Exp Clin Pharmacol. [Content Brief]

Butibufen Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Butibufen55837-18-8Othersanti-inflammatoryanalgesicantipyreticcell attachmentcell deathhepatocyteacid phosphataseoralInhibitorinhibitorinhibit

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