c-Myc inhibitor 15

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c-Myc inhibitor 15 (Compound A5) is a selective c-Myc inhibitor that exerts anticancer effects by disrupting the interaction between c-Myc and Max, leading to the degradation of c-Myc protein and the induction of apoptosis. Its IC₅₀ values are 4.08 μM and 7.86 μM in A549 and NCI-H1299 lung cancer cell lines, respectively, demonstrating strong cytotoxic activity. In a syngeneic tumor model, c-Myc inhibitor 15 exhibited outstanding antitumor efficacy, achieving a tumor growth inhibition rate of 76.4% and significantly reducing c-Myc protein expression levels. c-Myc inhibitor 15 holds promise for research related to c-Myc-driven lung cancers.

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c-Myc inhibitor 15 Chemical Structure

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Description	c-Myc inhibitor 15 (Compound A5) is a selective c-Myc inhibitor that exerts anticancer effects by disrupting the interaction between c-Myc and Max, leading to the degradation of c-Myc protein and the induction of apoptosis. Its IC₅₀ values are 4.08 μM and 7.86 μM in A549 and NCI-H1299 lung cancer cell lines, respectively, demonstrating strong cytotoxic activity. In a syngeneic tumor model, c-Myc inhibitor 15 exhibited outstanding antitumor efficacy, achieving a tumor growth inhibition rate of 76.4% and significantly reducing c-Myc protein expression levels. c-Myc inhibitor 15 holds promise for research related to c-Myc-driven lung cancers^[1].
Molecular Weight	457.57
Formula	C₂₇H₃₁N₅O₂
SMILES	N1(CCN2C(C=CC=C3)=C3N=C2C4=NOC(C5=CC=C(N6CCOCC6)C=C5)=C4)CCCCC1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Gao J, et al. Discovery of 4-(4-(3-(1-(2-(piperidin-1-yl) ethyl)-1H-benzo [d] imidazole-2-yl) isoxazol-5-yl) phenyl) morpholine as a novel c-Myc inhibitor against lung cancer in vitro and in vivo[J]. European Journal of Medicinal Chemistry, 2025, 281: 117023.