1. Protein Tyrosine Kinase/RTK Apoptosis
  2. VEGFR c-Met/HGFR c-Kit TAM Receptor FLT3 Apoptosis
  3. Cabozantinib-d4

Cabozantinib-d4  (Synonyms: XL184-d4; BMS-907351-d4)

Cat. No.: HY-13016S1
Handling Instructions

Cabozantinib-d4 is deuterium labeled Cabozantinib. Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.

For research use only. We do not sell to patients.

Cabozantinib-d<sub>4</sub> Chemical Structure

Cabozantinib-d4 Chemical Structure

CAS No. : 1802168-53-1

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Description

Cabozantinib-d4 is deuterium labeled Cabozantinib. Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

505.53

Formula

C28H20D4FN3O5

CAS No.
Unlabeled CAS

849217-68-1

SMILES

COC(C(OC)=C1)=CC2=C1C(OC(C=C3)=CC=C3NC(C4(CC4)C(NC5=C([2H])C([2H])=C(C([2H])=C5[2H])F)=O)=O)=CC=N2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Cabozantinib-d4
Cat. No.:
HY-13016S1
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