2. PROTAC Neuronal Signaling
  3. CaMK PROTACs
  4. CaMKIIα-PHOTAC

CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) targeting Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). Molecules such as PHOTAC can catalyze the ubiquitination and degradation of target proteins through the endogenous proteasome under specific wavelengths of light. CaMKIIα-PHOTAC reduces synaptic function under light conditions, and it attenuates the intensity of evoked field excitatory postsynaptic potentials in the mouse hippocampus in response to physiological stimuli. CaMKIIα-PHOTAC plays a critical role in maintaining long-term potentiation and memory capacity in subcellular dendritic domains.

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CaMKIIα-PHOTAC Chemical Structure

CaMKIIα-PHOTAC Chemical Structure

CAS No. : 2481744-33-4

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CaMKIIα-PHOTAC Related Antibodies

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Description

CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) targeting Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). Molecules such as PHOTAC can catalyze the ubiquitination and degradation of target proteins through the endogenous proteasome under specific wavelengths of light. CaMKIIα-PHOTAC reduces synaptic function under light conditions, and it attenuates the intensity of evoked field excitatory postsynaptic potentials in the mouse hippocampus in response to physiological stimuli. CaMKIIα-PHOTAC plays a critical role in maintaining long-term potentiation and memory capacity in subcellular dendritic domains[1].

IC50 & Target

CaMKIIα[1]
Molecular Weight

1094.00

Formula

C54H58Cl2N10O11
CAS No.
SMILES

O=C(COC1=C(OC)C=C(/N=N/C2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)C=C1OC)NCCCCCC(N5CCN(CCCOC6=C(OC)C=C7C(NC8=CC(OC)=C(Cl)C=C8Cl)=C(C#N)C=NC7=C6)CC5)=O
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Purity & Documentation
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CaMKIIα-PHOTAC Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CaMKIIα-PHOTAC2481744-33-4CaMKPROTACsCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesCAMKIIαPHOTACselectrophysiologyimmunohistochemistryprotein homeostasissynaptic functionInhibitorinhibitorinhibit

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