Carumonam disodium 

Carumonam disodium is a potent antibiotic. Carumonam disodium shows antibacterial activity. Carumonam disodium induces seizure^[1][2].

Carumonam disodium (0-100 µg/mL) shows antibacterial activity with MIC₉₀s of 0.2, 3.13, 0.2, 0.39, 0.2, 6.25, 0.2, 3.13, 0.05, 0.025, 0.78, 0.013, 0.025 µg/mL for Escherichia coli (cefazolin sensitive), Escherichia coli (cefazolin resistant), Klebsiella pneumoniae (cefazolin sensitive), Klebsiella pneumoniae (cefazolin resistant), Klebsiella oxytoca, Enterobacter cloacae, Serratia marcescens (gentamicin sensitive), Serratia marcescens (gentamicin resistant), Proteus vulgaris, Proteus mirabilis, Proteus morganii, Proteus rettgeri, Proteus inconstans, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Carumonam disodium (1.31-6.89 mmol/kg; i.p.) induces seizure in DBA/2, Swiss and C57 mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

510.37

C₁₂H₁₂N₆Na₂O₁₀S₂

86832-68-0

NC(OC[C@H]1N(C([C@H]1NC(/C(C2=CSC(N)=N2)=N\OCC(O[Na])=O)=O)=O)S(=O)(O[Na])=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Imada A, et al. In vitro and in vivo antibacterial activities of carumonam (AMA-1080), a new N-sulfonated monocyclic beta-lactam antibiotic. Antimicrob Agents Chemother. 1985 May;27(5):821-7.  [Content Brief]

  [2]. De Sarro A, et al. Comparative epileptogenic properties of two monobactam derivatives in C57, Swiss and DBA/2 mice. J Antimicrob Chemother. 1996 Sep;38(3):475-84.  [Content Brief]