1. Immunology/Inflammation Metabolic Enzyme/Protease
  2. Toll-like Receptor (TLR) Stearoyl-CoA Desaturase (SCD)
  3. 1345675-25-3

1345675-25-3

E6446 dihydrochloride Chemical Structure

1345675-25-3

Chemical Structure

  • E6446 dihydrochloride
  • CAS No: 1345675-25-3
    Formula: C27H37Cl2N3O3
    Molecular Weight: 522.51
  • IUPAC Name: 6-(3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazole dihydrochloride
  • InChIKey: DQOUZINBHKWGGM-UHFFFAOYSA-N
  • SMILES: [H]Cl.[H]Cl.C1(C2=CC=C(OCCCN3CCCC3)C=C2)=NC4=CC=C(OCCCN5CCCC5)C=C4O1

Biological Activity: E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD)[1][2][3].

Cat. No. Product Name Purity Description
HY-12756A E6446 dihydrochloride 99.96% E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD).

References