2. Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. HDAC DNA/RNA Synthesis Apoptosis
  4. 2217671-64-0

2217671-64-0

MIR002 Chemical Structure

2217671-64-0

Chemical Structure

  • MIR002
  • CAS No: 2217671-64-0
    Formula: C27H29NO5
    Molecular Weight: 447.52
  • IUPAC Name: (E)-3-(3'-(adamantan-1-yl)-4'-(2-(hydroxyamino)-2-oxoethoxy)-[1,1'-biphenyl]-4-yl)acrylic acid
  • InChIKey: YJMADWAPLKRSFA-FPYGCLRLSA-N
  • SMILES: ONC(COC1=C(C=C(C2=CC=C(C=C2)/C=C/C(O)=O)C=C1)C34CC5CC(CC(C5)C4)C3)=O

Biological Activity: MIR002 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. MIR002 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. MIR002 shows significant antitumor activity in vivo[1].

Cat. No. Product Name Purity Description
HY-143412 MIR002 ≥99.0% MIR002 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. MIR002 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. MIR002 shows significant antitumor activity in vivo.

References

[1]. Dallavalle S, et al. Antitumor activity of novel POLA1-HDAC11 dual inhibitors. Eur J Med Chem. 2022, 228:113971. [Content Brief]

Keywords:

MIR002