2. PI3K/Akt/mTOR
  3. mTOR
  4. 2382768-55-8

2382768-55-8

(32-Carbonyl)-RMC-5552 Chemical Structure

2382768-55-8

Chemical Structure

  • (32-Carbonyl)-RMC-5552
  • CAS No: 2382768-55-8
    Formula: C93H134N10O24
    Molecular Weight: 1776.11
  • InChIKey: CHLJLODIXLIFHL-VPQIPYMUSA-N
  • SMILES: NC1=C2C(C3=CC=C(OC(N)=N4)C4=C3)=NN(C2=NC=N1)CC5=CC=C(CN(CC6)C(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(O[C@H]7[C@@H](C[C@@H](CC7)C[C@H]([C@@]8([H])OC([C@@]9([H])N(CCCC9)C(C([C@@]%10(O[C@](CC[C@H]%10C)([H])C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@H](C([C@@H]([C@@H](/C(C)=C/[C@H](C(C8)=O)C)O)OC)=O)C)C)OC)O)=O)=O)=O)C)OC)=O)=O)C6=C5

Biological Activity: (32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2)[1].

Cat. No. Product Name Purity Description
HY-134903 (32-Carbonyl)-RMC-5552 95.41% (32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2).

References

[1]. Jennifer PITZEN, et al. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors. WO2019212990A1.

Keywords:

(32-Carbonyl)-RMC-5552