2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. 2568273-83-4

2568273-83-4

PROTAC SMARCA2/4-degrader-31 Chemical Structure

2568273-83-4

Chemical Structure

  • PROTAC SMARCA2/4-degrader-31
  • CAS No: 2568273-83-4
    Formula: C44H51N11O4
    Molecular Weight: 797.95
  • InChIKey: PUBFSJSCCCSWBL-KLIZRJGWSA-N
  • SMILES: OC1=CC=CC=C1C2=CC(N3CC(N4C5=NC(C6CCN([C@H]7CC[C@H](C8=CC(N(C)C(N9C%10CCC(NC%10=O)=O)=O)=C9C=C8)CC7)CC6)=NC=C5)CCC4C3)=C(N)N=N2

Biological Activity: PROTAC SMARCA2/4-degrader-31 (Compound I-280) is a degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-31 degrades SMARCA2 in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: Ligand for target protein (HY-163926); Black: Linker (HY-159682); Blue: Ligand for E3 ligase (HY-W382038))[1].

Cat. No. Product Name Purity Description
HY-162744 PROTAC SMARCA2/4-degrader-31 PROTAC SMARCA2/4-degrader-31 (Compound I-280) is a degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-31 degrades SMARCA2 in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: Ligand for target protein (HY-163926); Black: Linker (HY-159682); Blue: Ligand for E3 ligase (HY-W382038)).

References

[1]. Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.

Keywords:

PROTAC SMARCA2/4-degrader-31