2. Epigenetics Metabolic Enzyme/Protease
  3. Small Interfering RNA (siRNA) Apolipoprotein
  4. 21561-09-1

21561-09-1

WHI-P258 Chemical Structure

21561-09-1

Chemical Structure

  • WHI-P258
  • CAS No: 21561-09-1
    Formula: C16H15N3O2
    Molecular Weight: 281.31
  • IUPAC Name: 6,7-dimethoxy-N-phenylquinazolin-4-amine
  • InChIKey: MJKCGAHOCZLYDG-UHFFFAOYSA-N
  • SMILES: COC1=CC2=NC=NC(NC3=CC=CC=C3)=C2C=C1OC

Biological Activity: WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM[1][2].

Cat. No. Product Name Purity Description
HY-108419 WHI-P258 99.61% WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM.

References

[1]. Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82. [Content Brief]
[2]. Tibbles HE, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001 May 25;276(21):17815-22. [Content Brief]

Keywords:

WHI-P258