2. Epigenetics
  3. Histone Demethylase
  4. 2983011-81-8

2983011-81-8

LSD1-IN-19 Chemical Structure

2983011-81-8

Chemical Structure

  • LSD1-IN-19
  • CAS No: 2983011-81-8
    Formula: C33H42N6O2
    Molecular Weight: 554.73
  • IUPAC Name: 7-(benzyloxy)-N4-(1-benzylpiperidin-4-yl)-N2-(3-(dimethylamino)propyl)-6-methoxyquinazoline-2,4-diamine
  • InChIKey: CLMKFAVBRRFUGX-UHFFFAOYSA-N
  • SMILES: COC1=CC2=C(N=C(N=C2NC3CCN(CC3)CC4=CC=CC=C4)NCCCN(C)C)C=C1OCC5=CC=CC=C5

Biological Activity: LSD1-IN-19 (compound 29) is a potent, non-covalent and selective LSD1 inhibitor, with Ki of 0.108 μM and KD of 0.068 μM, respectively. LSD1-IN-19 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.17 and 0.40 μM, respectively[1].

Cat. No. Product Name Purity Description
HY-146284 LSD1-IN-19 LSD1-IN-19 (compound 29) is a potent, non-covalent and selective LSD1 inhibitor, with Ki of 0.108 μM and KD of 0.068 μM, respectively. LSD1-IN-19 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.17 and 0.40 μM, respectively.

References

[1]. Menna M, et al. Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem. 2022 Jul 5;237:114410. [Content Brief]

Keywords:

LSD1-IN-19