2. Epigenetics
  3. Histone Demethylase
  4. LSD1-IN-19

LSD1-IN-19 (compound 29) is a potent, non-covalent and selective LSD1 inhibitor, with Ki of 0.108 μM and KD of 0.068 μM, respectively. LSD1-IN-19 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.17 and 0.40 μM, respectively.

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LSD1-IN-19 Chemical Structure

LSD1-IN-19 Chemical Structure

CAS No. : 2983011-81-8

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LSD1-IN-19 Related Antibodies

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KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

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Description

LSD1-IN-19 (compound 29) is a potent, non-covalent and selective LSD1 inhibitor, with Ki of 0.108 μM and KD of 0.068 μM, respectively. LSD1-IN-19 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.17 and 0.40 μM, respectively[1].

IC50 & Target

KDM1/LSD1

 

Molecular Weight

554.73

Formula

C33H42N6O2
CAS No.
SMILES

COC1=CC2=C(N=C(N=C2NC3CCN(CC3)CC4=CC=CC=C4)NCCCN(C)C)C=C1OCC5=CC=CC=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LSD1-IN-19 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1-IN-192983011-81-8Histone Demethylaselow toxicityTHP-1 cellsMV4-11 cellsMDA-MB-231 cellsbreast cancerMDA-MB-231 TNBC cell lineRMS cellsLysine-specific demethylase 1 (LSD1)histone lysine methyltransferasesInhibitorinhibitorinhibit

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