2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. 170846-74-9

170846-74-9

CHPG Chemical Structure

170846-74-9

Chemical Structure

  • CHPG
  • CAS No: 170846-74-9
    Formula: C8H8ClNO3
    Molecular Weight: 201.61
  • IUPAC Name: 2-amino-2-(2-chloro-5-hydroxyphenyl)acetic acid
  • InChIKey: UNIDAFCQFPGYJJ-UHFFFAOYSA-N
  • SMILES: O=C(O)C(N)C1=CC(O)=CC=C1Cl

Biological Activity: CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways[2].

Cat. No. Product Name Purity Description
HY-101364 CHPG 99.51% CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.

References

[1]. Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO<sub>2</sub>-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 2015 Jun-Jul;85-86:46-52. [Content Brief]
[2]. Chen T, et al. The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med. 2012 Apr;29(4):630-6. [Content Brief]

Keywords:

CHPG