2. Stem Cell/Wnt
  3. β-catenin Wnt
  4. 2480284-01-1

2480284-01-1

hCAI/II-IN-4 Chemical Structure

2480284-01-1

Chemical Structure

  • hCAI/II-IN-4
  • CAS No: 2480284-01-1
    Formula: C15H15N3O5S2
    Molecular Weight: 381.43
  • IUPAC Name: cyclopropylmethyl 2-(4-sulfamoylbenzamido)thiazole-4-carboxylate
  • InChIKey: GNWGBZOLHBOSHB-UHFFFAOYSA-N
  • SMILES: O=C(C1=CSC(NC(C2=CC=C(S(=O)(N)=O)C=C2)=O)=N1)OCC3CC3

Biological Activity: hCAI/II-IN-4 (compound 6d) is a potent dual hCA I/II inhibitor with Ki values of 16.95, 15.22 and 27.04 nM for hCA I, hCA II and hCA Ⅸ, respectively. hCAI/II-IN-4 has anti-hypoxia activities and low toxicity. hCAI/II-IN-4 can be used for acute mountain sickness (AMS) research[1].

Cat. No. Product Name Purity Description
HY-147925 hCAI/II-IN-4 hCAI/II-IN-4 (compound 6d) is a potent dual hCA I/II inhibitor with Ki values of 16.95, 15.22 and 27.04 nM for hCA I, hCA II and hCA Ⅸ, respectively. hCAI/II-IN-4 has anti-hypoxia activities and low toxicity. hCAI/II-IN-4 can be used for acute mountain sickness (AMS) research.

References

[1]. Yang C, et al. N-Quinary heterocycle-4-sulphamoylbenzamides exert anti-hypoxic effects as dual inhibitors of carbonic anhydrases I/II. Bioorg Chem. 2020 Jul;100:103931. [Content Brief]

Keywords:

hCAI/II-IN-4