2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. CAXII-IN-1

CAXII-IN-1 (Compound 17) is a selective CA XII inhibitor with Ki values of 3.8 nM and 56.0 nM against hCA XII and hCA IX, respectively. CAXII-IN-1 shows antitumor activity.

For research use only. We do not sell to patients.

CAXII-IN-1 Chemical Structure

CAXII-IN-1 Chemical Structure

CAS No. : 2479918-59-5

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CAXII-IN-1 Related Antibodies

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CA CA I CA Ⅱ CA Ⅸ CA XII

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Description

CAXII-IN-1 (Compound 17) is a selective CA XII inhibitor with Ki values of 3.8 nM and 56.0 nM against hCA XII and hCA IX, respectively. CAXII-IN-1 shows antitumor activity[1].

IC50 & Target

IC50: 3.8 nM (hCA XII), 56.0 nM (hCA IX)[1]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
14 μM
Compound: 17
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32460112]
HeLa IC50
4.8 μM
Compound: 17
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32460112]
MCF7 IC50
20 μM
Compound: 17
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32460112]
In Vitro

CAXII-IN-1 (Compound 17) shows cytotoxicity with IC50 values of 20±1, 4.8±0.03 and 14±2 µM against MCF-7, HeLa and A549 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAXII-IN-1 Related Antibodies
Molecular Weight

328.17

Formula

C13H7Cl2NO3S
CAS No.
SMILES

ClC1=CC(Cl)=CC(C2=CN=C(OS(C=C3)(=O)=O)C3=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CAXII-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAXII-IN-12479918-59-5Carbonic AnhydraseCarbonate dehydrataseMCF-7HeLaA549antitumorInhibitorinhibitorinhibit

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HY-143460
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