CAXII-IN-1

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CAXII-IN-1 (Compound 17) is a selective CA XII inhibitor with K_i values of 3.8 nM and 56.0 nM against hCA XII and hCA IX, respectively. CAXII-IN-1 shows antitumor activity.

For research use only. We do not sell to patients.

CAXII-IN-1 Chemical Structure

CAS No. : 2479918-59-5

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Biological Activity
Purity & Documentation
References
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Description

CAXII-IN-1 (Compound 17) is a selective CA XII inhibitor with K_i values of 3.8 nM and 56.0 nM against hCA XII and hCA IX, respectively. CAXII-IN-1 shows antitumor activity^[1].

IC₅₀ & Target

IC₅₀: 3.8 nM (hCA XII), 56.0 nM (hCA IX)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	14 μM Compound: 17	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32460112]
HeLa	IC₅₀	4.8 μM Compound: 17	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32460112]
MCF7	IC₅₀	20 μM Compound: 17	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32460112]

In Vitro

CAXII-IN-1 (Compound 17) shows cytotoxicity with IC₅₀ values of 20±1, 4.8±0.03 and 14±2 µM against MCF-7, HeLa and A549 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

328.17

Formula

C₁₃H₇Cl₂NO₃S

CAS No.

2479918-59-5

SMILES

ClC1=CC(Cl)=CC(C2=CN=C(OS(C=C3)(=O)=O)C3=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Grandāne A, et al. Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII. Eur J Med Chem. 2020 Aug 15;200:112300. [Content Brief]

CAXII-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAXII-IN-12479918-59-5Carbonic AnhydraseCarbonate dehydrataseMCF-7HeLaA549antitumorInhibitorinhibitorinhibit

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