2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. CB2 receptor agonist 6

CB2 receptor agonist 6 (compound 70) is an agonist of CB2R, with EC50 of 162 nM. The IC50 values of CB2 receptor agonist 6 are 4.83 μM for CB1R and 0.88 μM for CB2R. CB2 receptor agonist 6 is a neuroprotective agent that can be used for the reseach of neurological disease.

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CB2 receptor agonist 6 Chemical Structure

CB2 receptor agonist 6 Chemical Structure

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CB2 receptor agonist 6 Related Antibodies

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Description

CB2 receptor agonist 6 (compound 70) is an agonist of CB2R, with EC50 of 162 nM. The IC50 values of CB2 receptor agonist 6 are 4.83 μM for CB1R and 0.88 μM for CB2R. CB2 receptor agonist 6 is a neuroprotective agent that can be used for the reseach of neurological disease[1].

IC50 & Target

CB2R

 

In Vitro

CB2 receptor agonist 6 (compound 70) (5 μM, 0/15/30/60 min) shows good metabolic stability in vitro [1].
CB2 receptor agonist 6 (5 μM, 0/0.5/1/1.5/2 h) can activate CB2R in vitro and inhibit cAMP expression in mice and humans[1].
CB2 receptor agonist 6 (0.01-10 μM, 90 min) shows selectivity to CB2R , with the values of Ki are 8.8 nM for CB1R and 0.89 nM for CB2R[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CB2 receptor agonist 6 Related Antibodies
In Vivo

CB2 receptor agonist 6 (compound 70) (1 mg/kg, intraperitoneal injection, predetermined intervals 0.25/0.5/1/2/6/24 h) can significantly reverse the forgetting effect of scopolamine-induced amnesia murine model, and does not affect the spatial learning and memory ability of naive mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Scopolamine-induced amnesia murine model[1]
Dosage: 0.1 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg
Administration: Subcutaneous injection (s.c.)
Result: Showed neuroprotective effects on scopolamine induced cognitive function in male mice.
Did not affect spatial learning and memory processes in naïve mice.
Molecular Weight

370.42

Formula

C24H19FN2O
SMILES

O=C(C1=CC=CN1CC2=CC=C(F)C=C2)NC3=CC(C4=CC=CC=C4)=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CB2 receptor agonist 6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB2 receptor agonist 6Cannabinoid ReceptorAmnesia murine modelCannabinoid systemNeurodegenerative diseasesNeuroinflammationMALDI imaging analysisAlzheimer’s disease (AD)Pharmacokinetic propertiesInhibitorinhibitorinhibit

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